Pulmonary computed tomography scan findings in chronic granulomatous disease

S.A. Mahdaviani, P. Mehrian, A. Najafi, S. Khalilzadeh, S. Eslampanah,A. Nasri, M. Bakhshayesh Karam, N. Rezaei, A.A. Velayati

Pediatric Respiratory Diseases Research Centre, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Background: Chronic granulomatous disease is a phagocyte defect, characterised by recur-rent infections in different organs due to a defect in NADPH oxidase complex. This study wasperformed to investigate pulmonary problems of CGD in a group of patients who underwentcomputed tomography (CT) scan.

Materials and Methods: Computed tomography scan was performed in 24 patients with CGD. The findings ofthe CT scan were documented in all of these patients.

Results: Areas of consolidation and scan formation were the most common findings, which weredetected in 79% of the patients. Other abnormalities in order of frequencies were as follows:small pulmonary nodules (58%); mediastinal lymphadenopathy (38%); pleural thickening (25%);unilateral hilar lymphadenopathy (25%); axillary lymphadenopathy (21%); bronchiectasis (17%);abscess formation (17%); pulmonary large nodules or masses (8%); and free pleural effusion(8%).

Conclusions: The pulmonary CT scans of the patients with CGD demonstrated a variety of respi-ratory abnormalities in the majority of the patients. While recurrent respiratory infections andabscesses are considered as prominent features of CGD, early diagnosis and precise check-upof the respiratory systems are needed to prevent further pulmonary complications.
Keywords: Chronic granulomatous disease, Computed tomography, Bronchiectasis, Pulmonary nodules, Respiratory infections

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Allergol Immunopathol (Madr). 2014 Sep-Oct;42(5):444-8