Allergic and Nonallergic Asthma in Children: Are They Distinct Phenotypes?

Seyed Alireza Mahdaviani, Seyed Amir Mohajerani*, Mohammad Fakhri, Mazaher Ebrahimi, Bahram Bashardoost, Seyed Jafar Razavi, Masoumeh Toolabi, Ali Tajik4, Soheila Khalilzadeh, and Mohamad Reza Masjedi

Pediatric Respiratory Diseases Research Centre, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

The aim of current study is to describe clinical similarities and differences between atopic and non-atopic asthma in children. In a cross-sectional study, 95 asthmatic children (75 allergics and 20 nonallergics) were included in the study. Demographic, clinical, and familial history were compared between two groups.

There was no significant differences between variables like sex, age of onset (p=0.75), severity (p=0.70), and family history among the two groups (p=0.42). Patients with allergic asthma were significantly older than those with non- allergic asthma (11.28±3.19 and 9.75±2.35 years, respectively, p=0.02).

The controversy lingers over the presence of a completely distinct phenotype of nonatopic asthma in children. Our study suggested that phenotypes of allergic and non-allergic asthma in children were not entirely distinct.
Keywords: Allergic; Asthma; Children; Non allergic; Phenotype

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Iran J Allergy Asthma Immunol. October 2014; 13(5):370-374