Association of Mycobacterium infections in patients with Mendelian susceptibility to mycobacterial disease with venous thromboembolism
Pediatric Respiratory Disease Research Centre, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
An association between a hypercoagulable state and Mendelian susceptibility to mycobacterial disease(MSMD) has been established in a few studies; resultant thrombosis is considered rare. In a case-control study, the prevalence of factor V Leiden,
Anomalous left brachiocephalic vein: important vascular anomaly concomitant with congenital anomalies and heart diseases
Pediatric Respiratory Disease Research Centre, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
The brachiocephalic (Innominate) veins are the two large veins of the thorax which are formed by the fusion of each corresponding internal jugular and subclavian veins at the level of the sternoclavicular joint. The left brachiocephalic vein (LBCV) is usually longer than the righ.
Characteristics of Tuberculosis among Children and Adolescents at a Referral TB’s Hospital, 2006 - 2011
Pediatric Respiratory Disease Research Centre, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Tuberculosis (TB) is a globally significant cause of morbidity and mortality in children. The world health organization(WHO) estimated the global burden of tuberculosis at 9.6 million new cases in 2014(1). In 2015, the WHO estimated that 1 million children develop TB worldwide
Characterization of Greater Middle Eastern genetic variation for enhanced disease gene discovery
Pediatric Respiratory Disease Research Centre, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
The GME, loosely defined as a large swath of Arab and non-Arab countries from Morocco in the west to as far east as Pakistan5, is home to approximately 10% of the world’s population. Despite the invaluable contribution of GME populations to the understanding of genetic
Lineage Switch in Childhood Leukemia: A Case Report and Review of Literature
Pediatric Respiratory Disease Research Centre, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Acute leukaemia is a heterogeneous group of clonal malignancies categorized as acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML) or mixed phenotype acute leukemia (MPAL.All subtypes have cytogenetic and molecular alterations that
ISG15 deficiency and increased viral resistance in humans but not mice
Pediatric Respiratory Disease Research Centre, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
nterferon-stimulated gene 15 (ISG15) is an interferon(IFN)-a/b-inducible ubiquitin-like molecule. It has two ubiquitin-like domains and is synthesized from an immature precursor by cleavage of a C-terminal extension peptide1. Mature ISG15 has the LRLRGG sequence
Long term outcome of cystic fibrosis patients with multisystem evaluation
Pediatric Respiratory Disease Research Centre, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Cystic fibrosis is a disease with multiple organ involvement that mainly results in chronic respiratory infections, pancreatic insufficiency and associated complications. The long-term outcome of multi-organ involvement has been studied by several researches; however, the point
Low prevalence of hepatitis B vaccine escape mutants among individuals born after the initiation of a nationwide vaccination program in Iran
Pediatric Respiratory Disease Research Centre, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Hepatitis B virus (HBV) infection is considered an important threat to public health and is a main cause of chronic hepatitis and hepatocellular carcinoma (HCC) [1]. Recent studies have revealed that more than a third of the world’s population has positive
